Draft federal clinical practice guidelines for the diagnosis, treatment, and prevention of vitamin D deficiency

This draft clinical practice guideline for the diagnosis, treatment and prevention of vitamin D deficiency is an update from a previous 2016 document. An analysis relevant literature data was carried out, with particular attention to meta-­analyzes, randomized trials systematic reviews published over past 5 years. The updated recommendations were discussed revised by leading endocrinologists Russian Federation, who have expert status in this issue. classification 25(OH)D levels has been (in particular, target range values specified), developed screening disorders associated deficiency. concept D-associated toxicity its diagnosis introduced. Also, indications assessment other metabolites besides 25(OH)D, main marker status, indicated. section regarding expanded corrected. major additions concerned replenishment insufficiency certain categories patients (particularly, presence chronic kidney disease autoimmune diseases, as well pregnant women) monitoring effectiveness safety therapy. prescribing active adjusted. Recommendations general population also revised, taking into account large trials, meta-analyzes recent publication version federal guidelines.